This message being spewed-forth by an asp.net application means that the DLL concerned has been compiled as a specific "bitness", but one that doesn't match that which IIS is running at. The most usual reason for this is an assembly marked as "x86" deployed to an "x64" server. If the assembly doesn't P/Invoke out to any 32-bit DLLs, change the platform target to "AnyCpu".

As far as the .net framework is concerned, the x86/x64 categorisation is only used as an indicator of requirements, thus if no P/Invoke is going on it's not needed, as the JIT compiler takes the assembly and JIT compiles it to the relevant instruction set at runtime anyway.